Symbol
Name
ID

Il6
interleukin 6
MGI:96559

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Monoclonal immunoglobulin M proteinemia

Polyclonal elevation of IgM

Epistaxis

Gingival bleeding

Gastrointestinal hemorrhage

Retinal hemorrhage

Purpura

Normocytic anemia

Impaired lymphocyte transformation with phytohemagglutinin

Abnormality of neutrophils

Leukemia

Acute myeloid leukemia

Hypercoagulability

Lymphoma

Hodgkin lymphoma

Elevated erythrocyte sedimentation rate

Splenomegaly

Disease(s) Associated with IL6

acute myeloid leukemia

Hodgkin's lymphoma

lymphoplasmacytic lymphoma

Mouse Phenotypes

abnormal osteoclast differentiation

abnormal B cell proliferation

decreased pro-B cell number

abnormal T cell differentiation

abnormal lymphocyte cell number

absent NK cells

decreased T cell number

abnormal T-helper 1 cell morphology

abnormal effector T cell morphology

abnormal microglial cell morphology

microgliosis

abnormal neutrophil physiology

impaired neutrophil recruitment

decreased IgA level

decreased IgE level

increased IgG2a level

abnormal T cell physiology

abnormal T-helper 1 physiology

abnormal T-helper 2 physiology

decreased cytotoxic T cell cytolysis

abnormal macrophage physiology

abnormal microglial cell physiology

abnormal osteoclast physiology

Availability

Mouse Genotype

Il6^tm1Kopf/Il6^tm1Kopf

Il6^tm1Kopf/Il6^tm1Kopf
Tg(Rorc-EGFP)1Ebe/?

Il6^tm1Mur/Il6^tm1Mur

Il6^tm1Poli/Il6^tm1Poli

Il6^tm1.1Jho/Il6^tm1.1Jho
Tg(GFAP-cre)8Gtm/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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